Infection of an organism by a pathogen triggers a complex host response that is necessary to protect the infected organism, but which also can contribute to lethal disease. How the host response is triggered and controlled and the mechanisms that determine the outcome of infection are not fully understood.
The OMICS-LHV (Lethal Human Viruses) project aims to develop a comprehensive understanding of the host response to unique viruses that cause lethal infections in humans by using a systems biology approach.
Our approach comprises:
- taking global measurements of changes in different host molecules in cells or tissues infected with these viruses;
- using computational analysis and modeling to make predictions about what controls these changes; and
- testing these predictions to refine the models.
The knowledge gained from this work is expected to provide a strong foundation for understanding the host response to lethal human virus pathogens, and could facilitate the development of improved strategies for intervening with lethal virus disease.
To accomplish our goal, we have assembled a multidisciplinary team of researchers with expertise in virology, mouse genetics, advanced high throughput technologies, computational modeling, and data management.